Fuller started off his junior season with two touchdowns on seven receptions for 142 yards against Texas. The following week, against the Virginia Cavaliers, Fuller caught five passes for 124 yards and two touchdowns, including the game-winning touchdown pass with 12 seconds left from DeShone Kizer. He had six receptions for 131 yards and a touchdown against Georgia Tech in Notre Dame's third game of the season, a 30–22 victory. Against USC, he recorded 3 receptions for 131 yards, including a 75-yard touchdown to beat USC, 41–31. At Pitt, Fuller caught seven passes for 152 yards and three touchdowns leading to 42–30 victory. His three touchdowns allowed him to surpass both Golden Tate and Jeff Samardzija on the career touchdown list with 28, leaving him only second behind Michael Floyd's 37. Fuller caught six passes for 113 yards, including an 81-yard touchdown, in a losing effort against Ohio State in the Fiesta Bowl. Fuller finished the season with 62 catches, career-high 1,258 yards with 14 touchdowns. He was named a second-team All-American by the Associated Press.