Fish began 2010 by winning the SAP Open in San Jose with doubles partner Sam Querrey. The pair defeated Benjamin Becker and Leonardo Mayer, 7–6, 7–5, in the final. With this win, Fish improves to 7–1 lifetime in ATP World Tour doubles finals. On March 27, Fish knocked his second round opponent Andy Murray out of the Sony Ericsson Open in Miami, Florida, in straight sets On June 10, Fish played Andy Murray again in the third round of the Queen's tournament in London. Fish won the first set 6–4, but lost the second 6–1. However, during the third set, Fish was leading 3–0, Murray then brought it back to 3–3. Fish then complained to the umpire that it was too dark, and he then walked off the court without talking to Murray. Murray stayed on the court for a few minutes after the incident and said, "He only complained because I was gaining momentum", and "He wouldn't have complained when he was 3–0 up. " The following day, Fish went on to win the third and final set in a 6–4, 1–6, 7–6 victory. He faced Michaël Llodra in the quarterfinals and Feliciano López in the semifinals to reach the final. He lost to compatriot Sam Querrey to finish as runner-up.