Brown began attending Central Michigan in 2007 after wide receivers coach Zach Azzanni told him he could fly to Michigan and try out for the team as a walk-on wide receiver. Transitioning from the quarterback position in high school to wide receiver in college was not that difficult for him, and after a few weeks, Central Michigan coaches offered him a scholarship. Brown had difficulty adjusting to the college lifestyle, and being on time for meetings and practice. Azzanni and his wife helped him get situated and into an established routine, and he soon became like a part of their family. He made his collegiate debut against Kansas on September 1. He had four receptions for 23 receiving yards in the 52–7 loss. In the next week's game against Toledo, he had nine receptions for 105 receiving yards and his first collegiate touchdown, a six-yard pass from Dan LeFevour, in the 52–31 victory. On October 6, against Ball State, he had six receptions for 43 receiving yards and a receiving touchdown to go along with a nine-yard rushing touchdown in the 58–38 victory. On November 23, against Akron, he had 15 receptions for 174 yards in the 35–32 victory. The Chippewas finished with an 8–5 record, won the MAC, and qualified for a bowl game. In the 2007 Motor City Bowl against Purdue, he had four receptions for 94 receiving yards and a receiving touchdown in the 51–48 loss. During his first season at Central Michigan, Brown played in 14 games. He played well enough to win the Mid-American Conference Freshman of the Year and was All-Conference as a returner. For his freshman season, he had 102 receptions for 1,003 yards and six touchdowns. His 102 receptions led the Mid-American Conference in 2007.