He finished the 2016 regular season ranked first in the SEC in passing yards (3,399) and second in passing yards per game (283. 3) and yards per completion (14. 34) while posted top-20 marks nationally in all three categories as well, peaking at 10th nationally with his 3,399 passing yards. Also ranked second in the SEC in completions per game (19. 75) and third in total offense (293. 5). His 3,399 yards through the air are the fifth-most in program history in a single season and the most ever in a 12-game season at Mizzou, while his 23 passing touchdowns were the sixth-most in program history and only three Mizzou quarterbacks have thrown for more in a single season. He completed 24-for-37 for a career-high 450 yards while tying a school record with five touchdowns against Eastern Michigan in Mizzou's home opener. He tossed for three more touchdowns on 23-of-38 passing in Mizzou's 28–27 loss to Georgia. His passing total of 1,106 yards was more than any Mizzou quarterback in his first three games ever. Played only the first half against Delaware State, but put up huge numbers in the 79–0 win. In the first half alone, he completed 26 of 36 passes for 402 yards while matching the school record with five touchdowns. He closed his season by sparking a second-half, 17-point comeback with a 67-yard TD pass to Johnathon Johnson against Arkansas. He finished that game going 16-for-26 with 268 yards and a score.