Estremeda had battled pulmonary fibrosis, a condition that is common among albino people. According to his wife, after Hurricane Maria struck Puerto Rico in September 2017, it became difficult for him to find the medications needed to treat his condition and this caused his health to deteriorate. On 2 November 2018, Estremera underwent a dual lung transplant operation at a hospital in Philadelphia, Pennsylvania. After almost a year of his surgery, Estremera was back in Puerto Rico, striving and undergoing physical therapy to regain strength in his legs. The dual lung transplant performed at Penn Medicine in Philadelphia was called an amazing success, however, during the next two years he would be in and out of hospitals until he died in San Juan, Puerto Rico on October 28 2020 at age 62. In his last hospital stay, Estremera told his wife, Yamira Arce, that he was tired and asked her, "to let him go". Arce said that he told her, "I'm checking in but I won't be leaving" (the hospital) and Arce also noted that Estremera's death was not due to coronavirus.