On February 26, 2018, Ionescu was named ESPNW's college basketball player of the week. Ionescu led the Ducks to their third regular-season league crown all-time and first-ever No. 1 seed in the Pac-12 Women’s Basketball Tournament. She led the Pac-12 in scoring (19. 2) and assists, dishing out 7. 8 assists per game which was fifth-most in the country. She had 16 double-doubles this season and 14 20-point games. She has recorded 10-assist games 13 times this season, handing out a league season-high 14 twice. Following her second season, she was named the Pac-12 Conference Women's Basketball Player of the Year, and was also named a first team All-American by ESPN. Ionescu's Oregon Ducks also won the Pac-12 championship for the first time since 2000. She was named the winner of the Nancy Lieberman Award as the top Division I women's point guard after the season, and was also a finalist for the Naismith Award. Ionescu became NCAA women's all-time leader in triple-doubles, trailing only former BYU men's player Kyle Collinsworth (with 12) among all NCAA players.