From 2004 to 2005, Loughlin co-created, produced, and starred in The WB drama series Summerland. She played Ava, the aunt who raises three children after their parents die in a car accident. The series was canceled after two seasons due to low ratings on July 11, 2005. In 2007, Loughlin co-starred in the ABC sitcom In Case of Emergency with David Arquette. She appeared in the film Moondance Alexander (2007), co-starring with her former Summerland castmate Kay Panabaker. Loughlin also was in attendance at Comedy Central's The Roast of Bob Saget which was hosted by John Stamos and premiered on August 17, 2008. At her table were Full House co-stars Dave Coulier and Jodie Sweetin. In 2010, Loughlin starred in the television film Meet My Mom, which premiered on the Hallmark Channel on Mother's Day. For the network, she most notably starred in the drama When Calls the Heart and the telefilm series Garage Sale Mystery before she was fired in 2019. On April 10, 2019 it was reported that When Calls The Heart would be returning after a production hiatus without Loughlin's character.